Hypocalcemia in thalassemia major patients requires an extra-careful approach

Thalassemia is a hematological disorder caused by gene mutation that leads to defective synthesis of hemoglobin complex. One the complications thalassemia hypocalcemia which presented with paresthesia, muscle spasm, low-serum calcium, and intracranial calcification. Hypocalcemia can affect thalassemic patients via various mechanisms. Blood transfusion-related transfusion-independent iron overload, drug side effects, vitamin D3 deficiency, genetic disorders polymorphisms are among etiologies in major thalassemia. A careful approach differential etiology this phenomenon crucial for resultful treatment.